Strona główna / Informator / Profesorowie i doktorzy habilitowani / prof. dr hab. Wojciech J. Stec

 

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prof. dr hab. Wojciech J. Stec

Professsor Wojciech Jacek STEC, Professor

 

Affiliation:

Department of Bioorganic Chemistry
Tel.: (+48-42)681-97-44, fax: (+48-42)681-54-83
e-mail: wjstec@cbmm.lodz.pl

 

 

Scintific career

   
1958 J.Śniadecki High School, Pabianice, Poland
1963 M.Sc., Chemistry, Technical University of Lodz
1968 Ph.D., Organic Chemistry; Technical University of Lodz,
Thesis: "Studies on the synthesis and chemical transformations of tetra-alkyl hypophosphates" (with Prof. A. Zwierzak) 
1973 Habilitation Degree, Organic Chemistry, Institute of Organic Chemistry, PAS, Warsaw.
Thesis: "Stereochemistry of nucleophilic substitution at phosphorus atom
1979 Assistant Professor (title confirmed and accepted by the State Council)
1979 Head of the Department of Bioorganic Chemistry, CMMS, PAS, Łódź, Poland 
1986 Full Professor (title confirmed and accepted by the State Council)  
1994 Corresponding Member of the Polish Academy of Sciences (elected) 
2006-2010 Vice President of the Polish Academy of Sciences (elected) 

 

Member of scientific organization (nominated or elected):


1982-present


Elected Member of "Societas Scientiarum ac Litterarum Varsoviensis" 

1994-present

Elected Corresponding Member of the Polish Academy of Sciences 

1999-2005

Member of the Presidium of the Polish Academy of Sciences 

2007-present Elected Full Member of the Polish Academy of Sciences

1999-present

Vice-President of the Board of Governors of the International Center for Genetic Engineering and Biotechnology (ICGEB, Trieste) 

 

Member of the Committee for Biotechnology; National Committee for Chemistry; Committee for Biochemistry and Biophysics

 

Member of editorial boards:


1976-1991


Member of the Editorial Board, "Polish Journal of Chemistry", Warsaw 

1989-1995

Member of the Editorial Board, "Heteroatom Chemistry. An International Journal of Main Group Elements" 

1993-present

Member of the Editorial Board "Antisense and Nucleic Acid Drugs and Development", N.Y., Ed. A. Krieg and C.A. Stein 

2000-2010

Member of the Editorial Board, "European Journal of Organic Chemistry", Germany 

2000-2010

Member of the Editorial Board, "ChemBioChem- An European Journal of Chemical Biology", Germany

   

Awards:


1972, 1975, 1977,
1979, 1985, 1988


Annual Awards of Scientific Secretary of the Polish Academy of Sciences 

1972

Annual Award of the Third Department of the Polish Academy of Sciences 

1978

Annual Award of the American Pharmacological Society for the best paper published (with four coauthors) in "Chemico-Biological Interactions" in 1977 

1987

Award of Lodz City Council 

1990

Kostanecki Medal (Annual Prize of the Polish Chemical Society) 

1991

NIH, Fogarty International Centre, "Fogarty Scholar-in-Residence Award”

1994

Marchlewski Medal (Annual Award of PAS Committee of Biochemistry and Biophysics) 

1994

The WIPO Medal for outstanding contribution in the field of Science and Biotechnology 

1996

Award of the Foundation of Experimental and Clinical Oncology, Poland 

1999 

Award of the Prime Minister of Poland for outstanding contribution to science 

2004

Award of the Foundation for Polish Science (the highest science distinction in Poland)

2005

Lodz City Award „Eureka”

2005

The Commander’s Cross of the Order of Merit of the Republic of Poland (presented by the President of Poland)

2006

Nomination for European Innovation Award (European Patent Office, Munich; Brussels)

2009

Jędrzej Śniadecki Medal for outstanding contribution into chemistry (Polish Chemical Society)

2010

Award of the Polish Biochemical Society  and Sigma-Aldrich Poland for  contribution to nucleic acids chemistry

2012 Doctor Honoris causa, Technical University of Lodz, Poland
2012 M.Curie-Sklodowska Medal (Polish Chemical Society)
2013 Polish-French (Société Chimique de France) Award
   

Current research area:


My research included oligonucleotides and their analogues, such as DNA phosphotriesters, oligo(nucleoside phosphorothioate)s, -phosphoroselenoate)s, -phosphoramidate)s and -methanephosphonate)s. Stereoselective synthesis, assignment of absolute configurations at phosphorus, analysis of "tacticity" of oligonucleotide analogues, their interactions with other biopolymers, and search for new effective tools for stereochemical assignments within new, unnatural oligonucleotide constructs, are the continuous goals of research programs performed in the Department of Bioorganic Chemistry. Besides protein engineering, such as h rec αTNF and its muteins (what somehow corresponded with my earlier studies on the synthesis of enantiomeric forms of anti-cancer drugs) my major efforts are directed towards medicinal applications of oligonucleotides and their phosphorothioate and methanephosphonate analogues within antisense-, antigene- and aptameric concepts of inhibition of protein biosynthesis. P-chiral phosphorothioates and isotopomeric phosphates are used as stereochemical probes for investigation of the mechanisms of enzymatic reactions involving phosphodiesterases, phosphoramidases, rybozymes, and others.


 

Selected recent references:

  1.  A.Krakowiak, R. Pawłowska, B. Kocoń-Rębowska, R. Dolot, W. J. Stec: Interactions of cellular Histidine triad nucleotide binding protein 1 with nucleosides 5'-O-monophosphorothioate and their derivatives – implication for desulfuration process in the cell. Biochim. Biophys. Acta - General Subject  2014, 1840: 3357–3366 (IF 3.829)
     
  2. A.Krakowiak, R. Pęcherzewska, R. Kaczmarek, A. Tomaszewska, B. Nawrot, W. J. Stec: Evaluation of influence of Ap(4)A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis. Bioorg. Med. Chem. 2011, 19: 5053-5060 (IF 2.951)
     
  3. A.Tomaszewska, P. Guga, W. J. Stec: Diastereomerically Pure Nucleoside-5’-O-(2-thio-4,4-pentamethylene-1,3,2-oxathiaphospholane)s - Substrates for Synthesis of P-Chiral Derivatives of Nucleoside-5’-O-phosphorothioates. Chirality 2011, 23(3): 237-244 (IF 1.724)
     
  4.  D.Błaziak, P. Guga, A. Jagiełło, D. Korczyński, A. Maciaszek, A. Nowicka, A. Pietkiewicz, W. J. Stec: Stereoselective formation of a P-P bond in the reaction of 2-alkoxy-2-thio-1,3,2-oxathiaphospholanes with O,O-dialkyl H-phosphonates and H-thiophosphonates. Org. Biomol. Chem. 2010, 8: 5505-5510 (IF 3.487)
     
  5.  R.Kaczmarek, J. Baraniak, W. J. Stec: A Novel approach to preparation of peptide-oligonucleotide conjugates (POCs). Synlett 2009, (14): 2269-2273 (IF 2.463)
     
  6.  P.Wang, B-K. Chun, S. Rachakonda, J. Du, N. Khan, J. Shi, W. Stec, D. Cleary, B. S. Ross, M. J. Sofia: An Efficient and Diastereoselective Synthesis of PSI-6130: A Clinically Efficacious Inhibitor of HCV NS5B Polymerase. J. Org. Chem. 2009, 74: 6819–6824 (IF 4.638)
     
  7.  B.Nawrot, N. Paul, B. Rebowska, W. J. Stec: Significance of Stereochemistry of 3’-Terminal Phosphorothioate-Modified Primer in DNA Polymerase-Mediated Chain extension. Mol. Biotech. 2008, 40(2): 119-126 (IF 2.275)
     
  8.  P.Guga, M. Boczkowska, M. Janicka, A. Maciaszek, S. Kuberski, W. J. Stec: Unusual Thermal Stability of RNA/[RP-PS]-DNA/RNA Triplexes Containing a Homopurine DNA Strand. Biophys. J. 2007, 92(7): 2507-2515 (IF 3.832)
     
  9.  K.Misiura, D. Szymanowicz, W. J. Stec: Synthesis of Nucleoside a-Thiotriphosphates via an Oxathiaphospholane Approach. Org. Lett. 2005, 7: 2217-2220 (IF 6.324)
     
  10.  J. L. Clark, L. Hollecker, J. Ch. Mason, L. J. Stuyver, P. M. Tharnish, S. Lostia, T. R. McBrayer, R. F. Schinazi, K. A. Watanabe, M. J. Otto, P. A. Furman, W. J. Stec, S. E. Patterson, K. W. Pankiewicz: Design, Synthesis, and Antiviral Activity of 2-Deoxy-2-Fluoro-2-C-methylcytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J. Med. Chem. 2005, 48: 5504-5508
    (IF 5.480)
     
  11.  A.Krakowiak, H. C. Pace, G. M. Blackburn, M. Adams, A. Mekhalfia, R. Kaczmarek, J. Baraniak, W. J. Stec, Ch.Brenner: Biochemical, Crystallographic, and Mutagenic Characterization of Hint, the AMP-Lysine Hydrolase, with Novel Substrates and Inhibitors. J. Biol. Chem. 2004, 279: 18711-18716 (IF 4.6)
     
  12. A.Guranowski, E. Starzyńska, A. G. McLennan, J. Baraniak, W. J. Stec: Adenosine-5-O-phosphorylated and Adenosine-5-O-phosphorothioylated Polyols as Strong Inhibitors of Symmetrical and Asymmetrical  Dinucleoside Tetraphosphates. Biochem. J. 2003, 373: 635-640 (IF IF 4.779)
     
  13. M.Koziołkiewicz, A. Owczarek, M. Wójcik, K. Domanski, P. Guga, W. J. Stec: Retention of the Configuration in the Action of Human Plasma 3'-Exonuclease on Oligo(deoxynucleoside phosphorothioate). A New Method for Assignment of Absolute Configuration at Phosphorus in Isotopomeric Deoxyadenosine 5'-O-[18O]-phosphorothioate. J. Am. Chem. Soc. 2002, 124: 4623-4627 (IF 11.444)
     
  14. M.Boczkowska, P. Guga, W. J. Stec: Stereodefined Phosphorothioate Analogues of DNA: Relative Thermodynamic Stability of the Model PS-DNA/DNA and PS-DNA/RNA Complexes. Biochem. 2002, 41: 12483-12487 (IF 3.194)
     
  15. P.Guga, K. Domanski, W. J. Stec: Oxathiapospholane Approach to the Synthesis of P-chiral, Isotopomeric Deoxyribonucleoside Phosphorothioates and Phosphates Labeled with Oxygen Isotope. Angew. Chem. Int. Ed. English, 2001, 40: 610-613 (IF 11.336)
     
  16. P.Guga, A. Okruszek, W. J. Stec: Recent Advances in Stereocontrolled Synthesis of P-Chiral Analogues of Biophosphates. In: Topics in Current Chemistry. Vol. 220, Springer Verlag Berlin Heidelberg 2001, J.P.Majoral, Ed., pp. 170-200.
     
  17. W .J. Stec, B. Karwowski, M. Boczkowska, P. Guga, M. Koziolkiewicz, M. Sochacki, M. W. Wieczorek, J. Blaszczyk: Deoxyribonucleoside 3'-O-(2-thio- and 3'-O-(2-oxo-"spiro"-4.4-pentamethylene-1.3.2-oxathiaphospholanes): Monomers for Stereocontrolled Synthesis of Oligo(nucleoside Phosphorothioate)s and Chimeric PS/PO Oligonucleotides. J. Am. Chem. Soc., 1998, 120: 7156-7167 (IF 11.444)
     
  18. W. J. Stec, A. Wilk: Stereocontrolled Synthesis of Oligo(nucleoside Phosphorothioate)s. Angew. Chem. Int. Ed. English 1994, 33: 709-722 (IF 11.336)
     
  19. M. Koziołkiewicz, W. J. Stec: The Application of Phosphate-Backbone Modified Oligonucleotides in the Studies on Eco RI Endonuclease Mechanism of Action. Biochemistry 1992, 31: 9460-9466 (IF 3.194)
     

See also complete list of publications (updated February 2015)  -> [WJ Stec List of publications February 2015.pdf,  410 KB]