Cross-linked Materials Team

Completed projects:

SONATA Project: „Thermo-sensitive supramolecular polymer networks formed by homodimerisation of molecular “clips”’ (UMO 2015/17/D/ST5/02458)_project leader: dr hab. Monika Gosecka

SONATA BIS Project: „Hydrogels composed of dynamic nodes with controlled permeability and enhanced drug solubility for potential gynaecological treatment (UMO-2018/30/E/ST5/00576)_project leader: dr hab. Monika Gosecka

https://www.ncn.gov.pl/przyklady-projektow/gosecka

Projects in progress:

Proof of Concept Project: „From the structure of the polymer network to in vivo application – the use of innovative hydrogel carriers of sparingly water-soluble drugs in the therapy of cervical cancer” (FENG.02.07-IP.05-0468/23.). Project leader: dr hab. Monika Gosecka

SONATA Project: „Plastic, covalent polyester networks made from plant waste” (UMO-2019/35/D/ST4/00862)_project leader: dr inż. Mateusz Gosecki

IUPAC Project:  “Nomenclature and terminology for supramolecular polymers” (# 2020-024-3-400)

Projekt OPUS: „Controlled-release hydrophilic and hydrophobic therapeutic compounds as potential dressings for the treatment of diabetic foot ulcers” (2023/49/B/ST11/03304)_project leader: dr hab. Monika Gosecka.

Doctoral theses

2025

2023
Piotr Kacper Ziemczonek „Hydrogels based on reversible network nodes as carriers of antimicrobial drugs for gynaecological applications” [20 November 2023]

Doctoral dissertation completed as part of the SONATA BIS project, NCN, entitled “Hydrogels constructed from dynamic network nodes with controlled permeability and increased drug solubility for potential gynaecological treatment”
(Project leader: dr hab. Monika Gosecka, prof. CBMiM PAN)

Supervisors: dr hab. Monika Gosecka, prof. CBMiM PAN
prof. Marcin Kozanecki, PŁ

Habilitation thesis

2021
Monika Gosecka “Reversible bonds in the design of polymer materials with thermo- and chemoresponsive properties”
[21 June 2021]

• Synthesis of reversibly cross-linked materials for biomedical applications, production of hydrogel drug carriers dedicated to gynaecological therapies, rheological analysis of the permeability of cross-linked polymer materials,
• Synthesis of thermosensitive and chemosensitive polymers and crosslinked polymer materials; investigation of the mechanisms of reversible polymer network formation using supramolecular interactions and reversible covalent interactions,
• Synthesis of plastic polyester networks from naturally sourced monomers.

1. Gosecka M., Jaworska-Krych D., Gosecki M., Urbaniak M., Wielgus E., Gostynski B., Marcinkowska M., Janaszewska A., Klajnert-Maculewicz B. “Construction of Dynamic Hydrogel Inducing Effective and Selective 5-Fluorouracil Monotherapy against Cervical
   Cancer Cells” ACS Applied Materials and Interfaces 2024, 17, 13427-13444
2. Jaworska-Krych D., Gosecka M., Maczugowska P., Halagan K., Szutkowski K., Gosecki M., Urbaniak M., Kozanecki M. “Thermosensitive Behavior of Internally Phenyl-Enriched Hyperbranched Polyglycidols in Water-The Influence of a Covalent Bond Used for the Hydrophobization” Macromolecules 2024, 57, 9135-9156
3. Jaworska-Krych D., Gosecka M., Gosecki M., Uraniak M., Dzitko K., Ciesielska A., Wielgus E., Kadlubowski S., Kozanecki M. “Enhanced Solubility and Bioavailability of Clotrimazole in Aqueous Solutions with Hydrophobized Hyperbranched Polyglycidol for
   Improved Antifungal Activity” ACS Applied Materials and Interfaces 2024, 16, 18434-18448
4. Yin B.H. , Gosecka M., Bodaghi M., Youssef G., Dodda J.M., Wong S.H.D., Bin Imran A., Gosecki M., Jobdeedamrong A., Naniz M.A., Zolfagharian A. “Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications” Chemical Engineering Journal 2024, 487, 150403
5. Gosecki M., Urbaniak M., Makarewicz C., Gosecka M. ”Converting Unrefined Birch Suberin Monomers into Vitrimer” ACS Sustainable Chem. Eng. 2024, 12, 9, 3841–3850
6. Gosecka M.*, Gosecki M., Ziemczonek P., Urbaniak M., Wielgus E.; Marcinkowska M.; Janaszewska A.; Klajnert-Maculewicz B. “Selective anti-cervical cancer injectable and self-healable hydrogel platforms constructed of drug-loaded cross-linkable unimolecular micelles in a single and combination therapy” ACS Applied Materials and Interfaces 2024
7. Gosecki M., Urbaniak, M. Urbaniak, Martinho N., Gosecka M.*, Zloh M. “Evaluation of Encapsulation Potential of Selected Star-Hyperbranched Polyglycidol Architectures: Predictive Molecular Dynamics Simulations and Experimental Validation” Molecules 2023, 28, 7308
8. Gosecka M.*, Gosecki M., Jaworska-Krych D., “Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications” Advanced Functional Materials 2023 https://doi.org/10.1002/adfm.202212302
9. Brettmann B.,  Fraga M. A., Gosecka M., Stingelin N. “Introduction to Polymer Upcycling”. J. Mater. Chem. A, 2023,11, 5975-5977
10. Gosecki M., Ziemczonek P., Gosecka M.*, Urbaniak M., Wielgus E., Marcinkowska M., Janaszewska A., Klajnert-Maculewicz B. “Cross-linkable star-hyperbranched unimolecular micelles for the enhancement of the anticancer activity of clotrimazole” Journal of Materials Chemistry B 2023, https://doi.org/10.1039/D2TB02629E
11. Gosecka M*, Jaworska-Krych D., Gosecki M., Wielgus E., Marcinkowska M., Janaszewska A., Klajnert-Maculewicz B. “Self-Healable, Injectable Hydrogel with Enhanced Clotrimazole Solubilization as a Potential Therapeutic Platform for Gynecology”. Biomacromolecules 2022, 23, 4203-4219
12. Gosecki, M. and Gosecka M., “Boronic acid esters and anhydrates as dynamic cross-links in vitrimers”. Polymers 2022, 14, 842
13. Gosecka M.*, Gosecki M., Urbaniak M. “Composite dynamic hydrogels constructed on boronic ester cross-links with NIR-enhanced diffusivity”. Biomacromolecules 2022; 23, 948-959
14.  “Oxidative esterification of aliphatic α,ω-diols, an alternative route to polyester precursors for the synthesis of polyurethanes” Gosecki M., Gosecka M., Urbaniak M. Polymer Chemistry 2021, doi.org/10.1039/D1PY01265G
15.  Gosecka M., Gosecki M., „Antimicrobial Polymer-Based Hydrogels for the Intravaginal Therapies-Engineering Considerations”  Pharmaceutics 2021, 13 (9)
16. “Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies” Ziemczonek P.; Gosecka M; Gosecki, M., Marcinkowska M., Janaszewska A., Klajnert-Maculewicz B. International Journal of Molecular Science 2021, 22 (16)
17.  “The influence of 2-acrylamidephenylboronic acid on the phase behaviour of its copolymers with N-isopropylacrylamide in aqueous solution”. Gosecki, M; Ziemczonek, P., Maczugowska, P., Czaderna-Lekka A., Kozanecki, M.; Gosecka, M. Polymer Chemistry 2021, 12, 3264-3275
18.  “A facile method to control the phase behavior of hydroxypropyl cellulose” Gosecki, M.; Setala, H.; Virtanen, T.; Ryan, A.J. Carbohydrate Polymers 2021, 251, 117015
19. “Synthesis of a monofunctional glycoluril molecular clip via cyclic imide formation on the convex site”. Urbaniak M., Gosecki M., Gostynski B., Gosecka M. New Journal of Chemistry 2020, 44, 596-604
20. “Influence of Glycoluril Molecular Clip Isomerization on the Mechanisms of Resorcinol Molecules Complexation”. Gosecki M., Urbaniak M., Gostynski B., Gosecka Journal of Physical Chemistry C 2020, 124, 8401-8410
21. “Glycoluril Clips for the Construction of Chemoresponsive Supramolecular Polymer Networks through Homodimer Cross-Links”. Gosecki M., Urbaniak M., Gosecka M., ChemPlusChem 2019, 84, 981-988
22. “Homodimerization driven self-assembly of glycoluril molecular clips with covalently immobilized poly(epsilon-caprolactone)”. Gosecka M., Urbaniak M., Mikina M., Gosecki M., Roznaski A., Soft Matter 2018, 14, 7945-7949
23. “Diffusion-Controllable Biomineralization Conducted In Situ in Hydrogels Based on Reversibly Cross-Linked Hyperbranched Polyglycidol” Gosecki M., Kazmierski S., Gosecka M., Biomacromolecules 2017, 18, 3418-3431
24. “DOSY NMR as a Tool for Predicting Optimal Conditions for Hydrogel Formation: The Case of a Hyperbranched Polyglycidol Cross-Linked with Boronic Acids” Gosecka M., Gosecki M., Kazmierski S., Journal of Polymer Science, Part B, Polymer Physics 2016, 54, 2171-2178
25. “Temperature-Induced Changes in the Nanostructure of Hydrogels Based on Reversibly Cross-Linked Hyperbranched Polyglycidol with B(OH)4^⊖ Ions” Gosecki M., Zgardzinska B., Gosecka M., Phys. Chem. C 2016, 120, 18323–18332;
26. “Characterization methods of polymer core-shell particles” Gosecka M., Gosecki M., Colloid Polym. Sci 2015, 293, 2719-2740