Serdecznie zapraszamy Państwa do wzięcia udziału w posiedzeniu Komisji Współdziałania Nauk Chemiczno-Biologiczno-Medycznych PAN, które odbędzie się w Centrum Badań Molekularnych i Makromolekularnych PAN (ul. Sienkiewicza 112, sala 09) w dniu 25 maja 2011 r. (środa) br. o godz. 11:30.
W programie spotkania wykład Prof. Hieronima Jakubowskiego (Department of Microbiology & Molecular Genetics, University of Medicine & Dentistry New Jersey) pt.:
The Homocysteine-Thiolactone Hypothesis: A Mechanism Underlying the Pathogenic Role of Homocysteine in Human Disease
Profesor Jakubowski był gościem naszej Komisji w maju 2010 roku i przedstawił wtedy stan wiedzy na temat modyfikacji białek resztą homocysteiny. Obecnie przestawi wyniki badań, które pozwalają na postawienie ważnej hipotezy na temat mechanizmu odpowiedzialnego za toksyczną rolę homocysteiny w patogenezie chorób układu sercowo-naczyniowego i nie tylko….
Serdecznie zapraszam do wzięcia udziału w naszym zebraniu.
Hieronim Jakubowski, Ph.D.Telephone: 973-972-4483 ext. 28733 (office), ext. 29111 (lab)
Hieronim Jakubowski was born in Szczecinek, Poland, in 1946. He obtained his M.S. degree in physical chemistry from the Poznan University (1969), Ph.D. degree in biochemistry from the Agricultural University, Poznan (1974), and D.Sc. degree in biochemistry from the Institute of Biochemistry and Biophysics, Warsaw (1979). He was a Postdoctoral Fellow at the University of New Mexico, Albuquerque, NM, USA (with Robert B. Loftfield, 1975–1976) and a FEBS Fellow at the Hanover Medical School, Germany (with Günther Maas, April 1982–July 1982). He was an EMBO Fellow at the Imperial College of Science and Technology, London, UK (with Alan Fersht, November 1980–December 1980), where he discovered biological synthesis of the thioester homocysteine thiolactone during homocysteine editing by aminoacyl-tRNA synthetases. He took a Yeast Genetics and Molecular Biology Course at the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA (July 1987–August 1987). His work focuses on the fidelity of amino acid selection by tRNA synthetases, error-editing mechanisms in protein biosynthesis, and mechanisms of homocysteine incorporation into protein, as well as on homocysteine-containing proteins and their role in human cardiovascular and neurodegenerative diseases. He has authored 140 peer-reviewed manuscripts and chapters and, with over 3,500 citations, is in the top 5% of cited authors for journals in Biology and Biochemistry. He has served in the National Institute of Health, American Cancer Society, and American Heart Association Study Sections and has been a Reviewer for NIH, NSF, American Chemical Society, US Army Research Office, Veterans Administration, and funding agencies in Poland, Switzerland, Israel, and France. He served on the Editorial Boards of Research Communications in Molecular Pathology & Pharmacology, Biomedicine & Pharmacotherapy, Journal ofAlzheimer’s Disease, Journal of Amino Acids, World Journal of Biological Chemistry, International Journal of Clinical and Experimental Medicine (IJCEM), and Acta Biochimica Polonica. He is currently a Professor of Microbiology and Molecular Genetics at New Jersey Medical School, Newark, NJ, USA, a Professor at the Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, and a Professor at the Department of Biochemistry and Biotechnology, University of Life Sciences, Poznan.
(Publications selected from 140 peer-reviewed publications)
1. Marczak L, Sikora M, Stobiecki M, Jakubowski H. Analysis of site-specific N-homocysteinylation of human serum albumin in vitro and in vivo using MALDI-ToF and LC-MS/MS mass spectrometry. J Proteomics 2011 Feb 15. [Epub ahead of print]
2. Ząbczyk M, Głowacki R, Machnik A, Heród P, Kazek G, Jakubowski H, Undas A. Elevated concentrations of Nɛ-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation. Clin Chem Lab Med. 2011, 49(4): 729-35.
3. Sikora M, Marczak L, Twardowski T, Stobiecki M, Jakubowski H. Direct monitoring of albumin lysine-525 N-homocysteinylation in human serum by LC/MS. Analytical Biochemistry 2010, 405(1): 132-4.
4. Suszynska J, Tisonczyk J, Lee HG, Smith MA, Jakubowski H. Reduced Homocysteine-Thiolactonase Activity in Alzheimer’s Disease. Journal of Alzheimers Disease 2010, 19(4): 1177-83.
5. Perla-Kajan J, Jakubowski H. Paraoxonase 1 protects against protein N-homocysteinylation in humans. FASEB Journal 2010; 24: 931-6.
6. Sikora M, Jakubowski H. Homocysteine editing and growth inhibition in Escherichia coli. Microbiology 2009, 155: 1858-65.
7. Jakubowski H, Perla-Kajan J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB Journal 2009, 23: 1721-7.
8. Jakubowski H, Boers GH, Strauss KA. Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans. FASEB Journal 2008, 22: 4071-6.
9. Jakubowski H. A new method for the determination of protein N-linked homocysteine. Analytical Biochemistry 2008, 380: 257-61.
10. Chwatko G, Boers GH, Strauss KA, Shih DM, Jakubowski H. Mutations in methylenetetrahydrofolate reductase or cystathionine β-syntase gene and high methionine diet increase homocysteine-thiolactone levels in humans and mice. FASEB Journal 2007, 21: 1707-13.
11. Perla-Kaján J, Marczak L, Kaján L, Skowronek P, Twardowski T, Jakubowski H. Modification by homocysteine thiolactone affects redox status of cytochrome c. Biochemistry 2007, 46: 6225-31.
12. Jakubowski H. The mechanism of the condensation of homocysteine-thiolactone with aldehydes. Chemistry – A European Journal 2006, 12: 8039-43.
13. Zimny J, Sikora M, Guranowski A, Jakubowski H. Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase. Journal of Biological Chemistry 2006, 281: 22485-92.
14. Taurog RE, Jakubowski H, Matthews RG. Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase. Biochemistry 2006, 45: 5083-91.
